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What is Mad Dog 357 plutonium made of? Extracts are crafted from pure HPLC certified capsicum and the clean tasting heat and sparkling flavor are consistent throughout the entire arsenal. These are a great start or supplement to any hot sauce collection.Jul 14, 2022 · What is the hottest hot sauce in the world? 1) Mad Dog 375 Plutonium No. The most extreme heat you can buy? The hottest hot sauce in the world is called Mad Dog 357 Plutonium No. 9 and comes in at 9 million Scoville Hotness Units (SHUs). This pepper extract is one of the hottest and purest in the entire world. Is the End hot sauce the hottest? I've heard that really spicy shit can kill you but only in the sense that it causes swelling of the mouth and throat, trouble breathing etc. I imagine a baby would definitely get fucked up from some atomic nut punch hotsauce. Strange_An0maly • 5 yr. ago. Probably.